A method to tighten the cloud screening thresholds based on local conditions is used to provide more stringent schemes for Orbiting Carbon Observatory-2 (OCO-2) cloud screening algorithms. Cloud screening strategies are essential to remove scenes with significant cloud and/or aerosol contamination from OCO-2 observations, which helps to save on the data processing cost and ensure high quality retrievals of the column-averaged CO2 dry air mole fraction (XCO2). Based on the radiance measurements in the 0.76 μm O2A band, 1.61 μm (weak), and 2.06 μm (strong) CO2 bands, the current combination of the A-Band Preprocessor (ABP) algorithm and Iterative Maximum A Posteriori (IMAP) Differential Optical Absorption Spectroscopy (DOAS) Preprocessor (IDP) algorithm passes around 20%–25% of all soundings, which means that some contaminated scenes also pass the screening process. In this work, three independent pairs of threshold parameters used in the ABP and IDP algorithms are sufficiently tuned until the overall pass rate is close to the monthly clear-sky fraction from the MODIS cloud mask. The tightened thresholds are applied to observations over land surfaces in Europe and Japan in 2016. The results show improvement of agreement and positive predictive value compared to the collocated MODIS cloud mask, especially in summer and fall. In addition, analysis indicates that XCO2 retrievals with more stringent thresholds are in closer agreement with measurements from collocated Total Carbon Column Observing Network (TCCON) sites.