Regions with high productivity of agriculture, such as the Beqaa Plain, Lebanon, often rely on groundwater supplies for irrigation demand. Recent reports have indicated that groundwater consumption in this region has been unsustainable, and quantifying rates of groundwater depletion has remained a challenge. Here, we utilize 15 years of data (June 2002–April 2017) from the Gravity Recovery and Climate Experiment (GRACE) satellite mission to show Total Water Storage (TWS) changes in Lebanon’s Beqaa Plain. We then obtain complimentary information on various hydrologic cycle variables, such as soil moisture storage, snow water equivalent, and canopy water storage from the Global Land Data Assimilation System (GLDAS) model, and surface water data from the largest body of water in this region, the Qaraaoun Reservoir, to disentangle the TWS signal and calculate groundwater storage changes. After combining the information from the remaining hydrologic cycle variables, we determine that the majority of the losses in TWS are due to groundwater depletion in the Beqaa Plain. Results show that the rate of groundwater storage change in the West Beqaa is nearly +0.08 cm/year, in the Rashaya District is −0.01 cm/year, and in the Zahle District the level of depletion is roughly −1.10 cm/year. Results are confirmed using Sentinel-1 interferometric synthetic aperture radar (InSAR) data, which provide high-precision measurements of land subsidence changes caused by intense groundwater usage. Furthermore, data from local monitoring wells are utilized to further showcase the significant drop in groundwater level that is occurring through much of the region. For monitoring groundwater storage changes, our recommendation is to combine various data sources, and in areas where groundwater measurements are lacking, we especially recommend the use of data from remote sensing.