We interpret space-borne observations from the TROPOspheric Monitoring Instrument (TROPOMI) in a multi-inversion framework to characterize the 2018–2019 global methane budget. Evaluation of the inverse solutions indicates that simultaneous source + sink optimization using methane observations alone remains an ill-posed problem – even with the dense TROPOMI sampling coverage. Employing remote carbon monoxide (CO) and hydroxyl radical (OH) observations with independent methane measurements to distinguish between candidate solutions, we infer from TROPOMI a global methane source of 587 (586–589) Tg yr−1 and sink of 571 Tg yr−1 for our analysis period. We apply a new downscaling method to map the derived monthly emissions to 0.1◦ × 0.1◦ resolution, using the results to uncover key gaps in the prior methane budget. The TROPOMI data point to an underestimate of tropical wetland emissions (a posteriori increase of +13 % [6 %–25 %] or 20 [7– 25] Tg yr−1 ), with adjustments following regional hydrology. Some simple wetland parameterizations represent these patterns as accurately as more sophisticated process-based models. Emissions from fossil fuel activities are strongly underestimated over the Middle East (+5 [2–6] Tg yr−1 a posteriori increase) and over Venezuela. The TROPOMI observations also reveal many fossil fuel emission hotspots missing from the prior inventory, including over Mexico, Oman, Yemen, Turkmenistan, Iran, Iraq, Libya, and Algeria. Agricultural methane sources are underestimated in India, Brazil, the California Central Valley, and Asia. Overall, anthropogenic sources worldwide are increased by +19 [11–31] Tg yr−1 over the prior estimate. More than 45 % of this adjustment occurs over India and Southeast Asia during the summer monsoon (+8.5 [3.1–10.7] Tg in July–October), likely due to rainfall-enhanced emissions from rice, manure, and landfills/sewers, which increase during this season along with the natural wetland source.